HBM Presents Phase I Data on Next-Generation Anti-CTLA-4 Antibody at ESMO Congress 2021

CAMBRIDGE,Mass. and ROTTERDAM,Netherlands and SUZHOU,China,July 26,2021 -- Harbour BioMed ("HBM",HKEX: 02142) today announced that the abstract detailing clinical data from its Australian phase I study of next-generation anti-CTLA-4 antibody in patients with advanced solid tumors will be presented as an e-poster at the 2021 European Society for Medical Oncology (ESMO) Congress,which is expected to be held 16-21 September 2021.

As the first fully human heavy chain only antibody (HCAb) under the clinical investigation,HBM4003 is generated from Harbour Mice® platform. This Study is an open-label,dose-escalating monotherapy study in treatment of advanced solid tumors. The preliminary clinical data demonstrate encouraging anti-tumor efficacy of HBM4003 with the good safety profile and tolerability. The data obtained from the Study have further validated pre-clinical findings of HBM4003's unique PK/PD profile,novel mechanism of action and low immunogenicity. The Company has proceeded with multiple global phase Ib/IIa trials in solid tumors in light of the encouraging clinical efficacy and safety profile.

About HBM4003

HBM4003 is the fully human anti-CTLA-4 monoclonal heavy chain only antibody (HCAb) generated from Harbour Mice®. By enhancing antibody-dependent cell cytotoxicity (ADCC) killing activity,HBM 4003 has demonstrated significantly improved depletion specific to high CTLA-4 Treg cells in tumor tissues. The potent anti-tumor efficacy and differentiated pharmacokinetics with durable pharmacodynamic effect presents a favorable product profile. This novel and differentiated mechanism of action has the potential to improve efficacy while significantly reducing the toxicity of the drug in monotherapy and combo-therapy.

About Harbour BioMed

Harbour BioMed (HKEX: 02142) is a global biopharmaceutical company committed to the discovery,development and commercialization of novel antibody therapeutics focusing on oncology and immunology. The Company is building its robust portfolio and differentiated pipeline through internal R&D capability,collaborations with co-discovery and co-development partners and select acquisitions.

The Company's proprietary antibody technology platforms Harbour Mice® generate fully human monoclonal antibodies in two heavy and two light chain (H2L2) format,as well as heavy chain only (HCAb) format. Building upon the HCAb antibodies,the HCAb-based immune cell engagers (HBICE™) are capable of delivering tumor killing effects unachievable by traditional combination therapies. Integrating Harbour Mice® with single B cell cloning platform,our antibody discovery engine is highly unique and efficient for development of next generation therapeutic antibodies.

For more information,please visitwww.harbourbiomed.com

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