I-Mab Announces Senior Management Team Share Purchase Plan

SHANGHAI andGAITHERSBURG,MD.,Jan. 6,2022 -- I-Mab (the "Company") (Nasdaq: IMAB),a clinical-stage biopharmaceutical company committed to the discovery,development,and commercialization of novel biologics,today announcedthat the senior management team of the Company,including Founder,Chairman and Acting CEO Dr. Jingwu Zang,President Dr. Andrew Zhu,Chief Financial Officer John Long,Chief Strategy Officer Jielun Zhu and Chief Business Officer Dr. Weimin Tang,have informed the Company of their intention to use their personal funds to purchase the Company's American depositary shares ("ADSs") on the open market for an aggregate amount of minimum US$3 million and up to US$20 million no later than February 28,2022.

"The share purchase plan demonstrates senior management team's strong confidence in the Company's global competitive pipeline and ongoing transformation towards an integrated global biopharma," said Dr. Jingwu Zang. "The Company's fundamentals remain very strong. In 2021,we successfully delivered planned important clinical and corporate milestones and will continue building on the strong momentum to deliver critical new milestones,including reporting multiple key clinical data readouts,initiating new registrational trials and accelerating dual listing on HKEX,continually creating value for patients and shareholders."

About I-Mab

I-Mab (Nasdaq: IMAB) is an innovation-driven global biopharma company focused on the discovery,development and commercialization of novel and highly differentiated biologics for immuno-oncology and autoimmune diseases. The Company's mission is to bring transformational medicines to patients around the world through innovation. I-Mab's globally competitive pipeline of more than 20 clinical and preclinical-stage drug candidates is driven by its internal discovery and global partnerships for in-licensing,based on the Company's Fast-to-Proof-of-Concept and Fast-to-Market development strategies. The Company is progressing from a clinical-stage biotech company into a fully integrated global biopharmaceutical company with cutting-edge R&D capabilities,a world-class GMP manufacturing facility,and commercial capability. I-Mab has established its global footprint in Shanghai (headquarters),Beijing,Hangzhou,Guangzhou,Lishui and Hong Kong in China,and Maryland and San Diego in the United States. For more information,please visithttp://ir.i-mabbiopharma.comand follow I-Mab onLinkedIn,Twitter,andWeChat.

I-Mab Forward-Looking Statements

This press release includes certain disclosures which contain "forward-looking statements." You can identify forward-looking statements because they contain words such as "anticipate" and "expected." Forward-looking statements are based on I-Mab's current expectations and assumptions. Because forward-looking statements relate to the future,they are subject to inherent uncertainties,risks and changes in circumstances that may differ materially from those contemplated by the forward-looking statements,which are neither statements of historical fact nor guarantees or assurances of future performance. Important factors that could cause actual results to differ materially from those in the forward-looking statements are set forth in filings with the U.S. Securities and Exchange Commission. I-Mab undertakes no obligation to publicly update or revise any forward-looking statements,whether as a result of new information,future events or otherwise,except as may be required by law.

I-Mab Contacts

John Long

Chief Financial Officer

john.long@i-mabbiopharma.com

+86 21 6057 8000

Gigi Feng

Chief Communications Officer

gigi.feng@i-mabbiopharma.com

+86 21 6057 5709

Investor Inquiries:

The Piacente Group,Inc.

Emilie Wu

E-mail: emilie@thepiacentegroup.com

Office line: + 86 21 6039 8363

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