111 to Announce Fourth Quarter and Fiscal Year 2021 Unaudited Financial Results on March 17, 2022 - Conference Call to Follow

SHANGHAI,Feb. 22,2022 --111,Inc. (NASDAQ: YI) ("111" or the "Company"),a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China,today announced that it will report its unaudited financial results for the fourth quarter and fiscal year 2021 ended December 31,2021,before the U.S. market opens on Thursday,March 17,2022.

111's management team will host an earnings conference call at 7:30 AM U.S. Eastern Time on Thursday,2022 (7:30 PM Beijing Time on the same day).

Details for the conference call are as follows:

Event Title:111,Inc. Fourth Quarter and Fiscal Year 2021 Unaudited Financial Results

Registration Link: http://apac.directeventreg.com/registration/event/7366837

All participants must use the link provided above to complete the online registration process in advance of the conference call. Upon registering,each participant will receive a set of participant dial-in numbers,the Direct Event passcode,and a unique Registration ID,which can be used to join the conference call.

Please dial in 15 minutes before the call is scheduled to begin and provide the Direct Event passcode and unique Registration ID you have received upon registering to join the call.

A telephone replay of the call will be available after the conclusion of the conference call until March 24,2022,8:59 ET on:

China:4006322162

United States: +1-855-452-5696

International: +61-2-8199-0299

Conference ID: 7366837

About 111,Inc.

111,Inc. (NASDAQ: YI) ("111" or the "Company") is a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China. The Company provides consumers with better access to pharmaceutical products and healthcare services directly through its online retail pharmacy,1 Pharmacy,and indirectly through its offline virtual pharmacy network. The Company also offers online healthcare services through its internet hospital,1 Clinic,which provides consumers with cost-effective and convenient online consultation,electronic prescription service,and patient management service. In addition,the Company's online platform,1 Medicine,serves as a one-stop shop for pharmacies to source a vast selection of pharmaceutical products. With the largest virtual pharmacy network in China,111 enables offline pharmacies to better serve their customers with cloud-based services. 111 also provides an omni-channel drug commercialization platform to its strategic partners,which includes services such as digital marketing,patient education,data analytics,and pricing monitoring.

For more information on 111,please visit:http://ir.111.com.cn/.

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