Akeso Publishes Preclinical Results of TIGIT monoclonal antibody（AK127）at the American Association for Cancer Research (AACR) 2022 Annual Meeting

HONG KONG,April 14,2022 --Akeso,Inc. (9926.HK) ( "Akeso" ),a China-based biopharmaceutical company focusing on the development and commercialization of innovative therapeutic antibodies for Oncology & Immunology,announced the publication of preclinical results of its anti-TIGIT monoclonal antibody (AK127) showing potent preclinical anti-tumor activities at the American Association for Cancer Research (AACR) Annual Meeting 2022.

Abstract：AK127,a novel monoclonal antibody (mAb) targeting T cell immunoreceptor (TIGIT)

https://www.abstractsonline.com/pp8/#!/10517/presentation/17743

AK127 is a novel humanized immunoglobulin (Ig) G1 monoclonal antibody (mAb) targeting T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT). AK127 specifically binds to TIGIT and blocks the interaction of TIGIT with its ligands,thus relieving immune suppression and promoting anti-tumor immune response.

Immune checkpoint blocking antibodies achieved great clinical success,yet a large fraction of cancer patients receive minimum benefit from current immunotherapies targeting PD-1 and CTLA-4. As a new multifunctional immune checkpoint molecule,TIGIT holds promise to become an important cancer immune therapy target.

The observations in AK127's preclinical study support the development of AK127 as an anti-tumor agent in the clinic：

AK127 blocked the immune inhibitory signal mediated by TIGIT,resulting in enhanced IL-2 secretion.

AK127 exhibited binding to FcγRIa,FcγRIIIa and C1q,and eliciting ADCC,ADCP and CDC.

In animal models,both AK104 (0.5 mg/kg) and AK127 (4 mg/kg) significantly inhibited tumor growth.

The combination of AK127 and AK104 produced a significantly enhanced anti-tumor effect than either monotherapy,demonstrating the synergistic anti-tumor activity of AK127 combined with AK104.

View original content to download multimedia:https://www.prnewswire.com/news-releases/akeso-publishes-preclinical-results-of-tigit-monoclonal-antibodyak127at-the-american-association-for-cancer-research-aacr-2022-annual-meeting-301525600.html