Preliminary Results from Two Clinical Studies of Selinexor to be Presented at 2022 ASH Annual Meeting

- Poster with updated Phase Ib TOUCH results suggest selinexor plus GemOx could provide a therapeutic option for heavily pre-treated Stage III/IV patients with relapsed/refractory (R/R) T and NK-cell lymphoma

- Online abstract with results from the open-label LAUNCH study demonstrated the encouraging efficacy of selinexor in combination with dexamethasone and chemotherapy in relapsed/refractory multiple myeloma (R/R MM) patients including high-risk cytogenetic abnormalities

SHANGHAI and HONG KONG,Nov. 6,2022 --Antengene Corporation Limited ("Antengene"SEHK: 6996.HK),a leading innovative,commercial-stage global biopharmaceutical company dedicated to discovering,developing and commercializing first-in-class and/or best-in-class medicines for hematology and oncology,today announced that it will present updated results from the Phase Ib TOUCH study of selinexor for treatment of R/R T and NK-cell lymphomain a poster at the upcoming 2022 American Society of Hematology (ASH) Annual Meeting. In addition,preliminary results from the investigator-initiated LAUNCH trial will be published in an on-line abstract. The 2022 ASH Annual Meeting will be held virtually and in person in New Orleans,Louisiana,the United States,from December 10-13,2022.

"The data to be presented at ASH 2022 highlights the broad clinical potential and manageable side effect profile of selinexor in patients with well-defined T-cell lymphomas and R/R MM," said Dr. Jay Mei,Antengene's Founder,Chairman and CEO. "It is our great pleasureto share these updates with the hematology/oncology community at ASH 2022."

Poster Presentation

Title: XPO1 Inhibitor (ATG-010) Plus GemOx Regimen for Heavily Pretreated Patients with Relapsed or Refractory (R/R) T and NK-Cell Lymphoma: Update of the Phase Ib Touch Study

Abstract #: 2916

Date: December 11,2022

Date and Time: 6:00 PM - 8:00 PM,ET / December 12,2022,7:00 AM – 9:00 AM,Beijing Time

The Phase Ib TOUCH study was designed to evaluate safety and efficacy of selinexor plus chemotherapy in patients with R/R T and NK-cell lymphoma. Antengene will report cumulative safety and efficacy data of 35 patients in the GemOx arm followed up for a median of 13 months and up to 22 months. Around 83% of the patients were clinically staged at III/IV,with a median of 3 lines of prior therapies. Disease subtypes included 15 PTCL-NOS (peripheral T-cell lymphoma,not otherwise specified),10 ENKTL (extranodal NK/T-cell lymphoma),9 AITL (angioimmunoblastic T-cell lymphoma) and 1 ALCL (anaplastic large cell lymphoma).

Treatment with ATG-010 plus GemOx demonstrated a manageable safety profile,and favorable efficacy especially in patients with PTCL-NOS and ENKTL. These data suggest that the combination of selinexor and GemOx could represent a new therapeutic option for this heavily pre-treated patient population.

From a safety perspective,treatment-emergent adverse events (TEAEs) were primarily hematological in nature and manageable by dose modification and supportive care. Among the 35 efficacy evaluable patients in the GemOx arm,overall response rate (ORR) was ~49% and complete response (CR) rate was 23%. At a median follow-up of 13 months,median progression-free survival (PFS) was 2.9 months and overall survival (OS) was not yet reached. Data for patients in the PTCL-NOS and ENKTL cohorts were relatively encouraging with a higher ORR of 53% and 60%,and a median PFS of 4.4 and 4.7 months,respectively.

Online Abstract Publication

Title: Preliminary Results from the Launch Study - a Multicenter,Open-Label Study of Selinexor,Dexamethasone and Chemotherapy Drugs in Relapsed/Refractory Multiple Myeloma

The LAUNCH study is a multi-center,open-label study to evaluate selinexor,dexamethasone and chemotherapy in patients with R/R MM who had at least one prior round of treatment. The abstract published data as of the July,2022 abstract deadline,for 20 patients including 7 who had high-risk cytogenetic abnormalities. Overall,the combination showed encouraging efficacy and manageable safety and support longer term studies.

Among the 18 efficacy evaluable patients,the ORR was ~56% including 1 very good partial response (VGPR),9 partial responses (PRs) and 5 stable diseases (SDs). Adverse events were reported in about 45-60% of patients and fell into two groups: hematological (~20-25% >Grade 3) and systemic (vomiting,fatigue and nausea,~0-10% >Grade 3).

About Antengene

Antengene Corporation Limited ("Antengene",SEHK: 6996.HK) is a leading commercial-stage R&D-driven global biopharmaceutical company focused on the discovery,development,manufacturing and commercialization of innovative first-in-class/best-in-class therapeutics for the treatment of hematologic malignancies and solid tumors,in realizing its vision of"Treating Patients Beyond Borders".

Since 2017,Antengene has built a broad and expanding pipeline of 15 clinical and preclinical assets,of which 10 are global rights assets,and 5 came with rights for Asia Pacific markets including the Greater China region. To date,Antengene has obtained 26 investigational new drug (IND) approvals in the U.S. and Asia,and submitted 6 new drug applications (NDAs) in multiple Asia Pacific markets,with the NDA for XPOVIO®(selinexor) already approved in mainland China,Taiwan,South Korea,Singapore and Australia.

Forward-looking statements

The forward-looking statements made in this article relate only to the events or information as of the date on which the statements are made in this article. Except as required by law,we undertake no obligation to update or revise publicly any forward-looking statements,whether as a result of new information,future events or otherwise,after the date on which the statements are made or to reflect the occurrence of unanticipated events. You should read this article completely and with the understanding that our actual future results or performance may be materially different from what we expect. In this article,statements of,or references to,our intentions or those of any of our Directors or our Company are made as of the date of this article. Any of these intentions may alter in light of future development. For a further discussion of these and other factors that could cause future results to differ materially from any forward-looking statement,see the section titled "Risk Factors" in our periodic reports filed with the Hong Kong Stock Exchange and the other risks and uncertainties described in the Company's Annual Report for year-end December 31,2021,and subsequent filings with the Hong Kong Stock Exchange.

For more information,please contact:

Investor Contacts:

Donald Lung

E-mail: Donald.Lung@antengene.com

Mobile: +86 18420672158

PR Contacts:

Peter Qian

E-mail: Peter.Qian@antengene.com

Mobile: +86 13062747000

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