111, Inc. Announces Third Quarter 2022 Unaudited Financial Results

SHANGHAI,Dec. 1,2022 – 111,Inc. ("111" or the "Company") (NASDAQ: YI),a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China,today announced its unaudited financial results for the third quarter ended September 30,2022.

Third Quarter 2022 Key Results

Net revenueswereRMB3.35 billion(US$470.8 million),representing an increase of 0.1% year-over-year.

Gross segment profit (1) increased by 21.6% year-over-year,with B2B segment profit increasing by 26.9% year-over-year.

Total operating expenseswereRMB282.7 million(US$39.7 million),compared to RMB341.4 million in the same quarter of last year. As a percentage of net revenues,total operating expenses decreased to 8.4% from 10.2% in the same quarter of last year,which reflected continuous improvement in our operation efficiency.

Non-GAAP loss from operations (2)wasRMB48.7 million(US$6.9 million),compared toRMB135.9 millionin the same quarter of last year. As a percentage of net revenues,non-GAAP loss from operations decreased to 1.5% from 4.1% in the same quarter of last year.

(1) Gross segment profit represents net revenues less cost of goods sold.

(2) Non-GAAP loss from operations represents loss from operations excluding share-based compensation expenses.

Mr. Junling Liu,Co-Founder,Chairman,and Chief Executive Officer of 111,commented,"Our business was negatively impacted by lockdowns in various cities and provinces during the third quarter. We have tried our very best to work with local governments as well as logistics companies to fulfill our customer/patient orders as these medicines are badly needed. Our net revenue for third quarter increased by 0.1% year-over-year to RMB3.35 billion,while our gross segment profit increased by 21.6% year-over-year. Non-GAAP loss from operations was narrowed to 1.5% of net revenues as compared to 4.1% in the same quarter of last year. We are also pleased to see our positive operating cash flow and overall cash flow for the quarter."

Mr. Liu added,"Our efforts to improve our margin profile continued to deliver positive results during the quarter. Our overall gross segment margin(3) as a percentage of net revenues improved to 6.0% from 5.0% in the same quarter of last year. B2B segment profit grew by 26.9% year-over-year,and as a percentage of net revenues,B2B segment margin improved to 5.5% from 4.4% in the same quarter of last year. We also improved B2C segment margin to 22.4% from 19.7% in the same quarter of last year. In addition,we continued to enhance our operation efficiency and total operating expenses as a percentage of net revenues decreased to 8.4% in this quarter from 10.2% in the same quarter of last year. We expect this momentum to continue as we scale,and meanwhile we will continue to focus on delivering best services to our customers/patients."

(3) Gross segment margin represents gross segment profit divided by net revenues.

Third Quarter 2022 Financial Results

Net revenueswereRMB3,349 million (US$470.8 million),representing an increase of 0.1% fromRMB3,346millionin the same quarter of last year.

(In thousands RMB)

For the three months ended September 30,

2021

2022

YoY

B2B Net Revenue

Product

3,205,763

3,225,201

0.6%

Service

16,188

23,716

46.5%

Sub-Total

3,221,951

3,248,917

0.8%

Cost of Products Sold(4)

3,080,411

3,069,316

-0.4%

Segment Profit

141,540

179,601

26.9%

Segment Profit %

4.4%

5.5%

(In thousands RMB)

For the three months ended September 30,

2021

2022

YoY

B2C Net Revenue

Product

116,069

90,941

-21.6%

Service

8,207

8,857

7.9%

Sub-Total

124,276

99,798

-19.7%

Cost of Products Sold(4)

99,751

77,417

-22.4%

Segment Profit

24,525

22,381

-8.7%

Segment Profit %

19.7%

22.40%

(4) For segment reporting purposes,purchase rebates are allocated to the B2B segment and B2C segments primarily based on the amount of cost of products sold for each segment. Cost of products sold does not include other direct costs related to cost of product sales such as shipping and handling expense,payroll and benefits of logistic staff,logistic centers rental expenses and depreciation expenses,which are recorded in the fulfillment expenses. Cost of service revenue is recorded in the operating expense.

Operating costs and expenseswereRMB3.4 billion(US$482.1million),representing a decrease of 2.6% fromRMB3.5 billionin the same quarter of last year.

Cost of products soldwasRMB3.1 billion(US$442.4 million),representing a decrease of 1.1% fromRMB3.2 billionin the same quarter of last year.

Fulfillment expenseswereRMB100.2 million(US$14.1 million),representing a decrease of 0.4% fromRMB100.6 millionin the same quarter of last year. Fulfillment expenses accounted for 2.99% of net revenues this quarter as compared to 3.01% in the same quarter of last year.

Selling and marketing expenses wereRMB107.8 million(US$15.2 million),representing a decrease of 18.2% fromRMB131.8millionin the same quarter of last year. We continued to see the improved sales efficiency and effectiveness. As a percentage of net revenues,selling and marketing expenses further reduced to 3.2% in the quarter from 3.9% in the same quarter of last year.

General and administrative expenses wereRMB46.1 million(US$6.5 million),representing a decrease of 13.1% fromRMB53.1 millionin the same quarter of last year. As a percentage of net revenues,general and administrative expense decreased to 1.4% in the quarter from 1.6% in the same quarter of last year.

Technology expenses were RMB29.5 million (US$4.2 million),representing a decrease of 47.3% from RMB56.1 million in the same quarter of last year. As a percentage of net revenues,technology expenses accounted for 0.9% this quarter as compared to 1.7% in the same quarter of last year.We completed major tech development programs last year and believe that current spending reflected the appropriate amount of investment in technology.

Loss from operationswasRMB80.7 million(US$11.3 million),compared toRMB175.4 millionin the same quarter of last year. As a percentage of net revenues,loss from operations decreased to 2.4% in the quarter from 5.2% in the same quarter of last year.

Non-GAAP loss from operationswasRMB48.7 million(US$6.9 million),compared toRMB135.9millionin the same quarter of last year. As a percentage of net revenues,non-GAAP loss from operations decreased to 1.5% in the quarter from 4.1% in same quarter of last year.

Net losswasRMB86.2 million(US$12.1 million),compared toRMB165.8 millionin the same quarter of last year. As a percentage of net revenues,net loss decreased to 2.6% in the quarter from 5.0% in same quarter of last year.

Non-GAAP net loss (5)wasRMB54.3 million(US$7.6 million),compared toRMB126.3 millionin the same quarter of last year. As a percentage of net revenues,non-GAAP net loss decreased to 1.6% in the quarter from 3.8% in same quarter of last year.

Net loss attributable to ordinary shareholders wasRMB96.8 million(US$13.6 million),compared toRMB252.9 millionin the same quarter of last year. As a percentage of net revenues,net loss attributable to ordinary shareholders decreased to 2.9% in the quarter from 7.6% in same quarter of last year.

Non-GAAP net loss attributable to ordinary shareholders (6)was RMB64.9 million (US$9.1 million),compared to RMB213.4 million in the same quarter of last year. As a percentage of net revenues,non-GAAP net loss attributable to ordinary shareholders decreased to 1.9% in the quarter from 6.4% in same quarter of last year.

(5) Non-GAAP net loss represents net loss excluding share-based compensation expenses,net of tax. Considering the impact of accretion of redeemable non-controlling interest for the third quarter 2022 (which pertains to the Group's obligation to redeem equity interests held by certain minority investors of a subsidiary of the Company),non-GAAP net loss is used as a meaningful measurement of the operation performance of the Company.

(6) Non-GAAP net loss attributable to ordinary shareholders represents net loss attributable to ordinary shareholders excluding share-based compensation expenses,net of tax.

As of September 30,2022,the Company has cash and cash equivalents,restricted cash and short-term investments of RMB865.9 million (US$121.7 million),compared to RMB943.2 million as of December 31,2021.

Conference Call

111's management team will host an earnings conference call at 7:30 AM U.S. Eastern Time on Thursday,December 1,2022 (8:30 PM Beijing Time on the same day).

Details for the conference call are as follows:

Conference Topic: 111,Inc. Third Quarter 2022 Earnings Conference Call

Registration Link: https://s1.c-conf.com/diamondpass/10026835-fg6ds.html

All participants must use the link provided above to complete the online registration process in advance of the conference call. Upon registering,each participant will then be provided with the dial in number,the Passcode,and the unique access PIN. This information will also be emailed to the participant as a calendar invite.

Please dial in 15 minutes before the call is scheduled to begin. To join the conference,simply dial the number in the calendar invite and enter the passcode followed by your PIN,and the participant will join the conference instantly.

A live and archived webcast of the conference call will be available on the website at https://edge.media-server.com/mmc/p/kpnswevm.

A telephone replay of the call will be available after the conclusion of the conference call until Dec 8,7:59 AM U.S. Eastern Time:

China: 4001209216

United States: +1-855-883-1031

International: +61-7-3107-6325

Conference ID: 10026835

Use of Non-GAAP Financial Measures

In evaluating the business,the Company considers and uses non-GAAP loss from operations,non-GAAP net loss,non-GAAP net loss attributable to ordinary shareholders,and non-GAAP loss per ADS,as supplemental measures to review and assess its operating performance. The Company defines non-GAAP loss from operations as loss from operations excluding share-based compensation expenses. The Company defines non-GAAP net loss as net loss excluding share-based compensation expenses,net of tax. The Company defines non-GAAP net loss attributable to ordinary shareholders as net loss attributable to ordinary shareholders excluding share-based compensation expenses,net of tax. The Company defines non-GAAP loss per ADS as net loss attributable to ordinary shareholders per ADS excluding share-based compensation expenses,net of tax per ADS. The presentation of these non-GAAP financial measures is not intended to be considered in isolation or as a substitute for the financial information prepared and presented in accordance with U.S. GAAP.

The Company believes that non-GAAP loss from operations,and non-GAAP loss per ADS help identify underlying trends in its business that could otherwise be distorted by the effect of certain expenses that it includes in loss from operations and net loss. Share-based compensation expenses is a non-cash expense that varies from period to period. As a result,management excludes the items from its internal operating forecasts and models. Management believes that the adjustments for share-based compensation expenses provide investors with a reasonable basis to measure the company's core operating performance,in a more meaningful comparison with the performance of other companies. The Company believes that non-GAAP loss from operations,and non-GAAP loss per ADS provide useful information about its operating results,enhances the overall understanding of its past performance and future prospects and allow for greater visibility with respect to key metrics used by the management in their financial and operational decision-making.

The non-GAAP financial measures are not defined under U.S. GAAP and are not presented in accordance with U.S. GAAP. The non-GAAP financial measures have limitations as analytical tools. One of the key limitations of using non-GAAP loss from operations,or non-GAAP loss per ADS is that it does not reflect all items of income and expense that affect the Company's operations. Further,the non-GAAP financial measures may differ from the non-GAAP information used by other companies,including peer companies,and therefore their comparability may be limited.

The Company compensates for these limitations by reconciling the non-GAAP financial measures to the most comparable U.S. GAAP measures,all of which should be considered when evaluating the Company's performance. The Company encourages you to review its financial information in its entirety and not rely on a single financial measure.

Reconciliation of the non-GAAP financial measures to the most comparable U.S. GAAP measures is included at the end of this press release.

Exchange Rate Information Statement

This announcement contains translations of certain RMB amounts into U.S. dollars at specified rates solely for the convenience of the reader. Unless otherwise noted,all translations from RMB to U.S. dollars are made at a rate of RMB7.1135 to US$1.00,the exchange rate set forth in the H.10 statistical release of the Board of Governors of the Federal Reserve System as of September 30,2022.

Forward-Looking Statements

This press release contains forward-looking statements. These statements constitute "forward-looking" statements within the meaning of Section 21E of the Securities Exchange Act of 1934,as amended,and as defined in the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements can be identified by terminology such as "will," "expects," "anticipates," "future," "intends," "plans," "believes," "estimates," "target," "confident" and similar statements. Among other things,the Business Outlook and quotations from management in this announcement,as well as 111's strategic and operational plans,contain forward-looking statements. 111 may also make written or oral forward-looking statements in its periodic reports to the U.S. Securities and Exchange Commission,in its annual report to shareholders,in press releases and other written materials and in oral statements made by its officers,directors or employees to third parties. Such statements are based upon management's current expectations and current market and operating conditions and relate to events that involve known or unknown risks,uncertainties and other factors,all of which are difficult to predict and many of which are beyond the Company's control. Forward-looking statements involve inherent risks,uncertainties and other factors that could cause actual results to differ materially from those contained in any such statements. Potential risks and uncertainties include,but are not limited to,uncertainties as to the Company's ability comply with extensive and evolving regulatory requirements,its ability to compete effectively in the evolving PRC general health and wellness market,its ability to manage the growth of its business and expansion plans,its ability to achieve or maintain profitability in the future,its ability to control the risks associated with its pharmaceutical retail and wholesale businesses,and the Company's ability to meet the standards necessary to maintain listing of its ADSs on the Nasdaq Global Market,including its ability to cure any non-compliance with Nasdaq's continued listing criteria. Further information regarding these and other risks,uncertainties or factors is included in the Company's filings with the U.S. Securities and Exchange Commission. All information provided in this press release is as of the date of this press release,and 111 does not undertake any obligation to update any forward-looking statement as a result of new information,future events or otherwise,except as required under applicable law.

About 111,Inc.

111,Inc. (NASDAQ: YI) ("111" or the "Company") is a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China. The Company provides consumers with better access to pharmaceutical products and healthcare services directly through its online retail pharmacy,1 Pharmacy,and indirectly through its offline virtual pharmacy network. The Company also offers online healthcare services through its internet hospital,1 Clinic,which provides consumers with cost-effective and convenient online consultation,electronic prescription service,and patient management service. In addition,the Company's online platform,1 Medicine,serves as a one-stop shop for pharmacies to source a vast selection of pharmaceutical products. With the largest virtual pharmacy network in China,111 enables offline pharmacies to better serve their customers with cloud-based services. 111 also provides an omni-channel drug commercialization platform to its strategic partners,which includes services such as digital marketing,patient education,data analytics,and pricing monitoring.

For more information on 111,please visit: http://ir.111.com.cn/.

For more information,please contact:

111,Inc.

Investor Relations

Email: ir@111.com.cn

111,Inc.

Media Relations

Email: press@111.com.cn

Phone: +86-021-2053 6666 (China)

111,Inc.

UNAUDITED CONDENSED CONSOLIDATED BALANCE SHEETS

(In thousands,except for share and per share data)

As of

As of

December 31,2021

September 30,2022

RMB

RMB

US$

ASSETS

Current Assets:

Cash and cash equivalents

661,390

720,729

101,318

Restricted cash

99,282

38,507

5,413

Short-term investments

182,556

106,710

15,001

Accounts receivable,net

404,469

422,853

59,444

Notes Receivable

90,734

73,233

10,295

Inventories

1,121,107

1,241,409

174,515

Prepayments and other current assets

242,199

188,515

26,501

Total current assets

2,801,737

2,791,956

392,487

Property and equipment,net

80,254

61,406

8,632

Intangible assets,net

4,909

3,740

526

Long-term investments

3,000

2,000

281

Other non-current assets

22,086

20,336

2,859

Operating lease right-of-use asset

233,847

175,521

24,675

Total Assets

3,145,833

3,054,959

429,460

LIABILITIES AND EQUITY

Current Liabilities:

Short-term borrowings

259,658

229,616

32,279

Accounts payable

1,347,352

1,547,943

217,606

Accrued expense and other current liabilities

522,968

480,563

67,555

Total Current liabilities

2,129,978

2,258,122

317,440

Long-term operating lease liabilities

165,614

115,046

16,173

Other non-current liabilities

1,537

(113)

(16)

Total Liabilities

2,297,129

2,373,055

333,597

MEZZANINE EQUITY

Redeemable non-controlling interests

1,000,849

1,042,801

146,595

SHAREHOLDERS' DEFICIT

Ordinary shares Class A

31

31

5

Ordinary shares Class B

25

25

4

Treasury shares

(40,859)

(40,859)

(5,744)

Additional paid-in capital

2,817,789

2,903,786

408,208

Accumulated deficit

(3,009,678)

(3,312,125)

(465,611)

Accumulated other comprehensive income

59,371

78,567

11,045

Total shareholders' deficit

(173,321)

(370,575)

(52,093)

Non-controlling interest

21,176

9,678

1,361

Total Deficit

(152,145)

(360,897)

(50,732)

Total liabilities,mezzanine equity and deficit

3,460

111,Inc.

UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS

(In thousands,except for share and per share data)

For the three months ended September 30，

For the nine months ended September 30,

2021

2022

2021

2022

RMB

RMB

US$

RMB

RMB

US$

Net Revenues

3,346,227

3,348,715

470,755

8,965,051

9,368,451

1,316,996

Operating Costs and expenses:

Cost of product sold

(3,180,162)

(3,146,733)

(442,361)

(8,548,640)

(8,781,967)

(1,234,549)

Fulfillment expenses

(100,561)

(100,167)

(14,081)

(250,960)

(282,608)

(39,728)

Selling and marketing expenses

(131,839)

(107,799)

(15,154)

(387,812)

(323,827)

(45,523)

General and administrative expenses

(53,064)

(46,121)

(6,484)

(156,630)

(132,609)

(18,642)

Technology expenses

(56,060)

(29,540)

(4,153)

(158,401)

(102,272)

(14,377)

Other operating expenses,net

103

976

137

(53)

(7,742)

(1,088)

Total Operating costs and expenses

(3,521,583)

(3,429,384)

(482,096)

(9,502,496)

(9,631,025)

(1,353,907)

Loss from operations

(175,356)

(80,669)

(11,341)

(537,445)

(262,574)

(36,911)

Interest income

2,031

2,558

360

8,217

6,022

847

Interest expense

(828)

(4,297)

(604)

(3,839)

(10,666)

(1,499)

Foreign exchange (loss) gain

(412)

(5,102)

(717)

374

(9,645)

(1,356)

Other Income,net

8,785

1,270

179

13,412

4,870

685

Loss before income taxes

(165,780)

(86,240)

(12,123)

(519,281)

(271,993)

(38,234)

Income tax expense

-

-

-

-

-

-

Net Loss

(165,234)

Net Loss attributable to non-controlling interest

7,533

3,532

497

23,284

11,498

1,616

Net Loss attributable to redeemable non-controlling interest

15,372

7,052

991

47,513

23,308

3,277

Adjustment attributable to redeemable non-controlling interest

(109,980)

(21,190)

(2,979)

(109,980)

(65,260)

(9,174)

Net Loss attributable to ordinary shareholders

(252,855)

(96,846)

(13,614)

(558,464)

(302,447)

(42,515)

Other comprehensive loss

Unrealized gains of available -for-sale securities,

2,556

1,034

145

6,057

3,810

536

Realized gains of available-for-sale debt securities

(2,114)

(721)

(101)

(5,642)

(3,184)

(448)

Foreign currency translation adjustments

765

9,385

1,319

(753)

18,570

2,611

Comprehensive loss

(251,648)

(87,148)

(12,251)

(558,802)

(283,251)

(39,816)

Loss per ADS:

Basic and diluted

(3.04)

(1.16)

(0.16)

(6.74)

(3.64)

(0.52)

Weighted average number of shares used in computation of loss per share

Basic and diluted

165,964,665

166,710,907

166,907

165,788,519

166,681

166,681

111,Inc.

UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(In thousands)

For the nine months ended September 30,

For the nine months ended September 30,

2021

2022

2021

2022

RMB

RMB

US$

RMB

RMB

US$

Net cash (used in) provided by operating activities

(107,181)

11,815

1,661

(374,694)

(86,361)

(12,140)

Net cash (used in) provided by investing activities

(243,454)

100,460

14,122

(126,869)

71,025

9,983

Net cash (used in) provided by financing activities

(5,307)

(40,755)

(5,729)

(115,889)

917

129

Effect of exchange rate changes on cash and cash equivalents,and

restricted cash

765

7,019

986

(753)

12,983

1,825

Net (decrease) increase in cash and cash equivalents,and restricted

cash

(355,177)

78,539

11,040

(618,205)

(1,436)

(203)

Cash and cash equivalents,and restricted cash at the beginning of the

period

1,055,506

680,697

95,691

1,318,534

760,672

106,934

Cash and cash equivalents,and restricted cash at the end of the period

700,329

759,236

106,731

700,731

111,Inc.

Unaudited Reconciliation of GAAP and Non-GAAP Results

(In thousands,except for share and per share data)

For the three months ended September 30,

2021

2022

2021

2022

RMB

RMB

US$

RMB

RMB

US$

Loss from operations

(175,356)

(80,669)

(11,341)

(537,445)

(262,574)

(36,911)

Add: Share-based compensation expenses

39,497

31,938

4,490

117,795

88,692

12,468

Non-GAAP loss from operations

(135,859)

(48,731)

(6,851)

(419,650)

(173,882)

(24,443)

Net Loss

(165,780)

(86,240)

(12,123)

(519,281)

(271,993)

(38,234)

Add: Share-based compensation expenses,net of tax

39,468

Non-GAAP net Loss

(126,283)

(54,302)

(7,633)

(401,486)

(183,301)

(25,766)

Net Loss attributable to ordinary shareholders

(252,515)

Add: Share-based compensation expenses,468

Non-GAAP net Loss attributable to ordinary shareholders

(213,358)

(64,908)

(9,124)

(440,669)

(213,755)

(30,047)

Loss per ADS: Basic and diluted

(3.04)

(1.16)

(0.16)

(6.74)

(3.64)

(0.52)

Add: Share-based compensation expenses per ADS,net of

tax

0.48

0.38

0.06

1.42

1.06

0.14

Non-GAAP Loss per ADS

(2.56)

(0.78)

(0.10)

(5.32)

(2.58)

(0.38)

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