Innovent Presents Co-developed Cancer-Fighting Tyvyt(R) (Sintilimab Injection) at CIIE 2019 with Eli Lilly

SUZHOU,China,Nov. 2,2019 -- Innovent Biologics (01801.HK),a multinational biopharmaceutical company,and Eli Lilly and Company presented their co-developed Tyvyt® (generic name: sintilimab injection),a fully human anti-programmed cell death protein 1 (anti-PD-1) monoclonal antibody at CIIE 2019. The medicine works to block the interaction of PD-1 with its ligands (PD-L1 and PL-L2) and consequently help patients restore the endogenous anti-tumour T-cell response. The new medical breakthrough,the result of the cooperation between the two companies,provides global patients with a more effective,safer treatment solution to fight cancer.

The world-leading anti-PD-1 inhibitor,Tyvyt®has been granted approval for market authorization by the National Medical Products Administration of China ("NMPA",formerly the China Food and Drug Administration) for the treatment of patients with classical cHL or relapsed or refractory r/r cHL Hodgkin's lymphoma following two or more lines of systemic chemotherapy. It also has been selected into the Guidelines of Chinese Society of Clinical Oncology (CSCO) for Lymphoid Malignancies in 2019. Sintilimab injection is currently undergoing 20 clinical studies,8 of which are registered clinical trials,to explore its application for a variety of solid tumors.

Topush the boundaries of global cooperation,Innovent Biologics established a strategic alliance with Eli Lilly and Company covering research,registration,production and market development,helping Chinese medical institutes to bring in new concepts on the journey to going global.

"International cooperation is one of the founding principles and core strategies of Invent biologics. The cooperation with Eli Lilly and Company in the field of cancer and diabetes is a testimony to our pursuit and efforts to build an international platform to create the best-in-class treatment for global patients," said Min Liu,Chief Business Officer of Innovent Biologics. "It is on this platform that we hope more excellent medical products can be introduced to China so patients can enjoy the benefits of Chinese scientific studies and significant medical findings globally."

Innovent Biologics has formed a groundbreaking biotech drug development collaboration with Eli Lilly since 2015. In the joint efforts to address the growing burden of cancer,the two companies are set to collaborate on the development and commercialization of at least three sintilimab-based cancer treatments over the next decade.

In August 2019,Innovent entered into a licensing agreement with Eli Lilly and Company for the development and commercialization of oxyntomodulin analog,OXM3. It has entered Chinaas a first-in-class dual GLP-1 and glucagon receptor agonist which is currently undergoing mid-stage clinical development. As part of a new partnership for developing the next-generation drugs of cancer immunotherapy,Eli Lilly is leading medical research and working with Innovent to introduce high-quality and affordable cancer-fighting products to China's market.

About Innovent

Inspired by the spirit of "Start with Integrity,Succeed through Action," Innovent's mission is to develop and commercialize high-quality biopharmaceutical products that are affordable to ordinary people. Established in 2011,Innovent is committed to developing,manufacturing and commercializing high-quality,innovative medicines for the treatment of oncology,autoimmunity and other major diseases. OnOctober 31,2018,Innovent was listed on the Main Board of the Stock Exchange of Hong Kong Limited with the stock code: 01801.HK.

About Eli Lilly and Company

Lilly is a global healthcare leader that unites caring with discovery to create medicines that make life better for people around the world. We were founded more than a century ago by a man committed to creating high-quality medicines that meet real needs,and today we remain true to that mission in all our work. Across the globe,Lilly employees work to discover and bring life-changing medicines to those who need them,improve the understanding and management of disease,and give back to communities through philanthropy and volunteerism.

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