Humoral immune response to SARS-CoV2 in Iceland

Titers of antibodies against SARS-CoV2 do not decline within four months

REYKJAVIK,Iceland,Sept. 2,2020 -- Scientists at deCODE genetics in Iceland,a subsidiary of Amgen Inc ,biopharmaceutical companyheadquartered in California,and their collaborators,today publish a study in The New England Journal of Medicine,that shows that antiviral antibodies against SARS-CoV2 do not decline within four months of diagnosis.

The aim of the study was to obtain understanding of the nature and durability of the humoral immune response to infection by SARS-CoV-2,the virus that causes COVID-19.

To that end the scientists measured antibodies in the sera of 30,576 persons in Iceland (8.4% of the nation) using six assays (two of them pan-Ig) and determined that the best measure of seropositivity was a positive result with both pan-Ig assays. They tested 2.102 samples from 1,237 qPCR-positive persons obtained up to 4 months from diagnosis. They also measured antibodies in4,222 samples from exposed,quarantined persons and 19000 persons not known to have been exposed.

Of quarantined persons,2.3% were seropositive and of those with unknown exposure,0.3% were positive.

The scientists estimate that 0.9% of Icelanders were infected by SARS-CoV-2 and 44% of people infected with SARS-CoV2 in Iceland were not diagnosed with qPCR. The infection fatality rate is 0.3%. Of the 1,797 persons who recovered from SARS-CoV-2 in Iceland,1,107 (91.1%) were seropositive.

"We are pleased to beable to put to rest the concern that the titer of the antiviral antibodies may decline within weeks of infection,says Kari Stefansson,CEO of deCODE genetics and senior author on the paper. Furthermore it is clear that 99,1% of Icelanders are still vulnerable to SARS-CoV2.We are now focused on studying cell mediated immunity in those who do not raise antibodies."

Based in Reykjavik,deCODE is a global leader in analyzing and understanding the human genome. Using its unique expertise in human genetics combined with growing expertise in transcriptomics and population proteomics and vast amount of phenotypic data,deCODE has discovered risk factors for dozens of common diseases and provided key insights into their pathogenesis. The purpose of understanding the genetics of disease is to use that information to create new means of diagnosing,treating and preventing disease. deCODE is a wholly-owned subsidiary of Amgen (NASDAQ:AMGN).

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Contact:

Thora Kristin Asgeirsdottir

PR and Communications

deCODE genetics

thoraa@decode.is

354 894 1909