Akeso is rapidly advancing the clinical study of the PD-1/CTLA-4 bispecific antibody Cadonilimab combined with TIGIT monoclonal antibody for the teratment of solid tumors

HONG KONG,Oct. 22,2021 --Akeso,one of leading Chinese pharmaceutical innovation company announces that the first patient was dosed in a phase I clinical trial of the Company's independently developed TIGIT monoclonal antibody (AK127) in combination with the Company's global first-in-class Cadonilimab (PD-1/CTLA-4 bi-specific antibody,AK104) for the treatment of advanced or metastatic solid tumors in Australia.

This is an open-label,multicenter phase I clinical trial designed to evaluate the safety,tolerability,pharmacokinetic,immunogenicity,pharmacodynamics and anti-tumor activity of AK127 in combination with Cadonilimab in subjects with advanced or metastatic solid tumors.

Clinical trials have demonstrated promising efficacy of TIGIT monoclonal antibody in combination with PD-1 monoclonal antibody in immuno-oncology therapy. Cadonilimab simultaneously targets the two well-established immune checkpoints,PD-1 and CTLA-4. Preclinical studies showed that the combination of AK127 and Cadonilimab produced a significantly enhanced anti-tumor effect in mice model.

Based on the promising efficacy seen in both preclinical and clinical studies on TIGIT monoclonal antibody in combination with PD-1 monoclonal antibody therapy,AK127 in combination with Cadonilimab has the potential to demonstrate significant anti-tumor activity in treating patients with solid tumors,further enhance the potential and outlook of combination therapy,and strengthen and enrich the Company's multi-target portfolio in immuno-oncology therapy.

By developing a rich pipeline of therapeutic antibodies for the treatment of cancer,the Company seeks to transform the treatment paradigm in the immuno-oncology space with combination therapies against various immune targets; and realise the full commercial value of its bi-specific antibodies that are based on a PD-1 antibody backbone. Currently,clinical trials such as Cadonilimab in combination with CD47 monoclonal antibody ( AK117),VEGFR-2 monoclonal antibody (AK109),CD73 monoclonal antibody (AK119) and PD-1/VEGF (AK112) in combination with AK117,have all been successfully initiated.

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