OriCell Therapeutics Raises Over $120 Million in Series B Financing Led by Qiming Venture Partners and Quan Capital to Advance Cell Therapies for Cancer Immunology

2022 is set to be a milestone year for OriCell who has been focusing on the field of cancer immunotherapy for more than seven years and is fully committed to becoming an innovative global drug developer.

SHANGHAI,Aug. 1,2022 -- OriCell Therapeutics (Shanghai) Co.,Ltd. ("OriCell" or "the Company") has announced the completion of Series B financing totaling over US$120 million. This round of financing was jointly led by Qiming Venture Partners and Quan Capital with participation by several leading international and Chinese investment funds,as well as existing shareholder C&D Emerging Capital. The new funding will go toward the development of OriCell's cell therapy pipeline,and Company's proprietary discovery platform,as well as the construction of a manufacturing plant for both clinical and commercial purposes.

Helen Yang,Chairman and CEO of OriCell,stated,"We are grateful to our new and existing investors for their continued support in OriCell. We have achieved a number of significant milestones in terms of clinical development of our CAR-T and partnered bispecific antibody programs,as well as continued to strengthen our senior management team. We look forward to delivering more innovative discoveries and clinical milestones in the next three years. In today's open,inclusive,and dynamic innovative pharmaceutical ecosystem in China,we endeavor to become a world leading cell therapy company with a broad vision that can integrate seamlessly into the global market."

OriCell's Investigational New Drug (IND) submission for Ori-C101,Company's first internally developed CAR-T product targeting GPC3 for the treatment of advanced liver cancer,was accepted by the National Medical Products Administration (NMPA) of China in June of this year. In data published at the 2021 American Society of Clinical Oncology (ASCO) annual meeting,Ori-C101 demonstrated superior safety and efficacy in patients with GPC3-positive advanced liver cancer with an objective response rate (ORR) of 44% and disease control rate (DCR) of 78%. The longest follow-up thus far is more than 22 months,with additional follow-ups ongoing.

OriCAR-017,China's first GPRC5D CAR-T product developed by OriCell for the treatment of relapsed and refractory multiple myeloma (RRMM) confirmed the product's potential with clinical results from the investigator-initiated phase I trial (POLARIS) was presented in an oral presentation at the 2022 ASCO and EHA2022 annual meetings,respectively. In all patients,the majority of adverse events (AE) were transient,manageable,and reversible. Only Grade 1/2 cytokine release syndrome (CRS) was observed with no dose limiting toxicity(DLT),neurotoxicity,or AE-related death. Responses were durable and deepened over time with 100% ORR and 100% MRD negative rate,including in 5 prior BCMA CAR-T relapsed patients. All patients were progression-free and followed up without additional therapy by the cutoff date of April 30,2022. Presently,OriCell is accelerating its registration and clinical development in China and the United States.

An exclusive global license agreement for Ori®Bs-001 (ATG101) was reached with Antengenein 2019. Ori®Bs-001 (ATG101) is a PD-L/4-1BB bispecific antibody and has received the implied approval from the Center for Drug Evaluation (CDE) in China in March this year after receiving IND from the U.S. Food and Drug Administration (FDA) and Clinical Trials Notification (CTN) from the Australian Therapeutic Goods Administration (TGA).

In March this year,Dr. Weidong Cui joined the company as Chief Technology Officer. Dr. Cui has more than 20 years of experience in process development,GMP production and commercial operation of cell therapy drug products. As the former CTO at Fosun Kite,he has led the team to successfully complete the GMP production,IND registration,and NDA registration of the first CAR-T drug in China.

About OriCell Therapeutics

Founded in 2015,OriCell Therapeutics aims to develop novel immunotherapies to satisfy globally unmet clinical needs. OriCell has constructed 4 versatile and patented technology platforms: Ori®Ab antibody discovery technology platform,Ori®CAR CAR-T technology platform featuring high memory and high vitality,Ori®TIL,a stable and controllable cell culture platform for efficient expansion,and Ori®UCAR,a universal,convenient,and efficient CAR-T technology platform.

Visit www.oricell.comfor more information.

Forward-looking statements

The forward-looking statements made in this article relate only to the events or information as of the date on which the statements are made in this article. Except as required by law,we undertake no obligation to update or revise publicly any forward-looking statements,whether as a result of new information,future events or otherwise,after the date on which the statements are made or to reflect the occurrence of unanticipated events. You should read this article completely and with the understanding that our actual future results or performance may be materially different from what we expect. In this article,statements of,or references to,our intentions or those of any of our Directors or our Company are made as of the date of this article. Any of these intentions may alter in light of future development.

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