Insilico Medicine Signs Strategic Research Collaboration with Sanofi worth up to $1.2 Billion

Agreement includes aggregate upfront and target nomination fees of up to $21.5 million for up to 6 targets,and additional R&D and sales milestones plus tier-based mid-single- to low double-digit royalties.

New York,Nov. 8,2022 -- Insilico Medicine,a clinical stage artificial intelligence (AI)-driven drug discovery company,announced a multi-year,multi-target strategic research collaboration with Sanofi. Under the terms of the agreement,the collaboration will leverage Insilico Medicine's AI platform,Pharma.AI,to advance drug development candidates for up to six new targets.

"We look forward to working with Insilico Medicine,a demonstrated leader in AI-powered drug discovery," said Changchun Xiao,Head of China Research at Sanofi. "This collaboration will leverage our complementary capabilities,as well as the co-location of our scientific teams,to boost the drug discovery efforts of the Sanofi Institute for Biomedical Research (SIBR),Sanofi's R&D center in China."

Under the terms of the agreement,Sanofi will pay Insilico Medicine a total of up to $21.5 million covering the upfront and target nomination feesto benefit from Insilico's end-to-end Pharma.AI platform and gain access to a team of interdisciplinary drug discovery scientists to identify,synthesize,and advance high-quality lead therapeutic compounds up to development candidate stage. Additional payments will be made if key research,development,and sales milestones are met,and could total up to $1.2 billion. The collaboration also establishes mid-single to up to low double-digit tiered royalties for any products developed.

"We are very happy to collaborate with Sanofi,a company with a clear strategy in AI-powered drug discovery," said Alex Zhavoronkov,PhD,CEO and founder of Insilico Medicine. "This close collaboration will allow Sanofi to immediately gain the capabilities of one of the top AI startups in addition to enriching their drug discovery pipeline."

"We are thrilled to collaborate with Sanofi. Leveraging Sanofi's strong drug research and development expertise and Insilico's powerful AI platform,we believe we can accelerate novel therapeutics discovery to address diseases with unmet medical needs," said Feng Ren,co-CEO and Chief Scientific Officer of Insilico Medicine. "Together we will use cutting-edge AI technologies to make significant breakthroughs in drug R&D."

About Insilico Medicine

Insilico Medicine,a clinical stage end-to-end artificial intelligence (AI)-driven drug discovery company,is connecting biology,chemistry,and clinical trials analysis using next-generation AI systems. The company has developed AI platforms that utilize deep generative models,reinforcement learning,transformers,and other modern machine learning techniques to discover novel targets and to design novel molecular structures with desired properties. Insilico Medicine is delivering breakthrough solutions to discover and develop innovative drugs for cancer,fibrosis,immunity,central nervous system (CNS) diseases and aging-related diseases.

For more information,visitwww.insilico.com

For business development inquiries,contact bd@insilicomedicine.com