ExoCoBio obtained a US Patent for Rose Stem Cell-derived Exosome (RSCE™)

- The first plant stem cell-derived exosome patent in the US

- The 5th patent allowance following 3 in Korea and 1 in Japan

- An important milestone for the global plant stem cell-derived exosome industry

SEOUL,South Korea,May 19,2023 -- ExoCoBio,one of the top three exosome companies in the world,announced that it has obtained a patent (US Application No: 17/141,693) from the US Patent and Trademark Office for a cosmetic composition containing rose stem cell-derived exosomes or extracellular vesicles.

In this patent,ExoCoBio used its proprietary technology ExoSCRT™ process to mass-culture stem cells derived from roses and isolate high-purity exosomes (RSCE™) from the culture medium. Various efficacy evaluations were performed on the mass-produced RSCE™,resulting in a significant increase in collagen production from human skin fibroblasts.

As of April 2023,ExoCoBio currently holds a total of 54 patents,including five patents related to RSCE™,and 14 scientific publications including submitted manuscripts internationally. The existing patents for RSCE™ cover the effects of collagen increase (KR 10-2058444),whitening by melanin reduction (KR 10-2261434),anti-inflammatory effects by IL-6 reduction,and wound healing by accelerated cellular migration (KR 10-2341932).

Compared to existing plant exosome-related patents of simple extraction of exosomes contained from plant juice,ExoCoBio's method is distinctive as it specifically mass-cultures plant stem cells and employs its proprietary technology,ExoSCRT™ to separate and purify high-purity exosomes. RSCE™ has been demonstrated to be easily delivered to human skin fibroblasts,with a higher survival rate for human hair cells compared to conventional rose stem cell culture medium filtrate.

In addition,the analysis of RSCE™ revealed that it contains about 200 types of miRNAs and more than 90 types of proteins,some of which are similar to those found in humans.

To enable the industrial application of RSCE™,ExoCoBio has already registered them as a cosmetic ingredient (INCI Name: Rosa Damascena Callus Extracellular Vesicles) with the Personal Care Products Council (PCPC) in the United States in 2020 (see attachment 3).

In March 2023,the ASCE+™ product line received the "The Best Cosmetics" award at The Aesthetic and Anti-aging Medicine World Congress (AMWC),the world's top anti-aging congress held in Monaco.

Mr. Byong Cho,CEO/CTO of ExoCoBio,said,"To make new scientific discoveries and create new exosome industries,we have been significant investment in the research and development of plant stem cell-derived exosomes,including roses,over the past four years. We believe that the plant exosome field is in the early stages and has a very high potential for industrial application. In particular,with the most data and patents,ExoCoBio has been at the forefront of plant stem cell-derived exosome research worldwide.

About Exocobio Co.,Ltd. (www.exocobio.com)

ExoCoBio,a renowned exosome biotech firm ranked among the top three globally,boasts exclusive global expertise in exosomes and specializes in the development of exosome-based biotechnology and cosmeceuticals. The company is leading the advancement of exosome-based medical aesthetics,offering innovative solutions to enhance damaged skin worldwide,including prominent regions such as the United States,Europe,and Japan.

What is Exosome?

Exosomes are vesicles composed of various bioactive substances of nano size (30-200 nm) that serve as key signaling molecules between cells in our body. They are secreted for intercellular communication and play a crucial role in inducing immune regulation or activation in recipient cells,thereby influencing the microenvironment surrounding the cells. Exosomes have the potential to target specific cells and enhance the efficacy of active ingredients,making them highly promising for applications in various fields such as cosmetics,diagnostics,and therapeutics.

RSCE™ Patent

RSCE™ TEM (Transmission Electron Microscope) Image

RSCE™ Registration to PCPC & INCI