Winners of the 2019 Breakthrough Prize in Life Sciences, Fundamental Physics and Mathematics Announced

A TOTAL OF $22 MILLION AWARDED FOR BREAKTHROUGHS IN TREATMENT FOR THE LEADING GENETIC CAUSE OF INFANT DEATH,SUPER-RESOLUTION IMAGING,DISCOVERY OF A NEW KIND OF ELECTRONIC MATERIAL,AND OTHER MAJOR ACHIEVEMENTS

2019 Breakthrough Prize in Life Sciences Awarded to C. Frank Bennett and Adrian R. Krainer,Angelika Amon,Xiaowei Zhuang,and Zhijian "James" Chen

2019 Breakthrough Prize in Fundamental Physics Awarded to Charles Kane and Eugene Mele

2019 Breakthrough Prize in Mathematics Awarded to Vincent Lafforgue

Six "New Horizons" Prizes Worth $600,000 Awarded for Early-Career Achievement in Physics and Math

All Laureates – including Jocelyn Bell Burnell,Recipient of 2018 Special Breakthrough Prize in Fundamental Physics – to be Honored at Live Televised Ceremony on Sunday,November 4

SAN FRANCISCO,Oct. 17,2018 --The Breakthrough Prize Foundation and its sponsors – Sergey Brin,Priscilla Chan and Mark Zuckerberg,Ma Huateng,Yuri and Julia Milner and Anne Wojcicki – announced today the recipients of the 2019 Breakthrough Prize,awarding a collective total of $22 million to nine researchers for important achievements in the Life Sciences,Fundamental Physics and Mathematics.

The 2019 Breakthrough Prize and New Horizon Prize recipients will be recognized at the seventh annual Breakthrough Prize ceremony,known as the "Oscars of Science," hosted by acclaimed actor,producer and philanthropist Pierce Brosnan,on Sunday,November 4,at NASA Ames Research Center in Mountain View,California,and broadcast live on National Geographic.

Considered the world's most generous science prize,each Breakthrough Prize is for $3 million. Now in its seventh year,the Prize recognizes achievements in the Life Sciences,Fundamental Physics and Mathematics,the disciplines that ask the biggest questions and find the deepest explanations.

The discoveries recognized this year include:

In the Life Sciences,a spectacularly successful gene therapy drug,Spinraza,that treats Spinal Muscular Atrophy,a deadly infant disease;

A super-resolution imaging technology that transcends traditional light microscopy revealing entirely new internal structures of cells;

The revelation of a mechanism by which cells detect foreign DNA and trigger immune response,with implications for cancer and autoimmune diseases;

And,insight into how abnormal numbers of chromosomes are implicated in almost all cancers and can otherwise wreak havoc in the human body.

In Fundamental Physics,mind-bending theoretical advances including the discovery of a new class of electronic materials that simultaneously conduct and resist electricity and could prove transformative for quantum computing.

And in Mathematics,for elegant and groundbreaking contributions to the Langlands program in the function field case.

In addition to the seven main-stage prizes,a total of six New Horizons Prizes,worth $100,000 each,were awarded to seven physicists and five mathematicians for early-career achievements in their respective fields. Full citations can be found below.

The 2019 Breakthrough Prize and New Horizon Prize recipients will be recognized at the Breakthrough Prize ceremony,or the "Oscars of Science," on Sunday,November 4. The gala-event,hosted by acclaimed actor,will bring together luminaries of the science and tech communities with celebrities,athletes and musicians,all attending with the common goal of celebrating science and scientific achievement. This year's ceremony will be broadcast live on Nat Geo,YouTube and Facebook Livefrom the NASA Ames Research Center in Mountain View,California.

In September,an additional Special Breakthrough Prize in Fundamental Physics was announced,recognizing British astrophysicist Jocelyn Bell Burnell for her role in the surprise discovery of pulsars – an exotic new type of star – first announced in February 1968,and for her inspiring scientific leadership over the last five decades.

2019 Breakthrough Prize | Categories | Citations | Descriptions

BREAKTHROUGH PRIZE IN LIFE SCIENCES

C. Frank Bennett and Adrian R. Krainer – IonisPharmaceuticals and Cold Spring Harbor Laboratory,respectively

Citation:For the development of an effective antisense oligonucleotide therapy for children with the neurodegenerative disease spinal muscular atrophy.

Description: Spinal Muscular Atrophy (SMA) is a rare but devastating disease– the leading genetic cause of infant death. Many children with SMA die before their second birthday. Now it is no longer a death sentence.Frank Bennett,a pharmacologist,andAdrian Krainer,a biochemist,built upon their discoveries about antisense technology and thenatural process of RNA splicingto produce the first drug to treat SMA – Nusinersen (marketed by Biogen as Spinraza). It was approved by the FDA in 2016 and is one of the first of a promising new breed ofantisense therapies now in developmentfor familial dysautonomia (FD),glioblastoma and liver cancer. The work has also paved the way for the possibility of new therapies using gene silencing modalities for Huntington's,ALS,spinocerebellar ataxias,Parkinson's and Alzheimer's.Bennettgrew up in his family's hotel,in Aztec,New Mexico. With a nudge from guidance counselors,he pursued pharmacology instead,and developed a passion for finding cures for really awful diseases.Krainergrew up in Montevideo,Uruguay,of Eastern European descent. He admired Gregor Mendel's work,and as a high school student developed an interest in genetics. Bennett and Krainer,previously aware of each other's work,joined forces in 2004 to research SMA and have collaborated ever since.

Angelika Amon – Massachusetts Institute of Technology and Howard Hughes Medical Institute

Citation:For determining the consequences of aneuploidy,an abnormal chromosome number resulting from chromosome mis-segregation.

Description: An extrachromosomecan lead to devastating consequences (Down Syndrome,miscarriage,etc.) In fact,80 percent of all cancers have either extraor missing chromosomes.

Viennese-born molecular biologistAngelika Amonhas shown howirregularities in the number of chromosomes ("aneuploidy") produces a stress response and disrupts the cell's fail-safe,error-repair system – which in turn allows genetic mutations to quickly accumulate.She is hopeful that an understanding of the consequences of aneuploidy will shed light on cancer evolution and help to identify new therapeutic targets for cancer,building upon her work on the cellular vulnerabilities caused by aneuploidy.Amon lives by what she calls 'the grandma test' – an idea has to be easily explainable to pique her interest. Sheasks simple questions to get big answers.

Xiaowei Zhuang–Harvard UniversityandHoward Hughes Medical Institute

Citation:For discovering hidden structures in cells by developing super-resolution imaging – a method that transcends the fundamental spatial resolution limit of light microscopy.

Description: Xiaowei Zhuangwas a child prodigy.At age six,she was able to identify the atmospheric force acting upon a glass of water,impressing her father,an aerodynamics professor at China's leading science andtechnologyuniversity.Years later,a post-doc at Stanford at the dawn of thegolden age of microscopy,she channeled herpassion for physics into bioimaging and an exploration of biological systems. In her lab at Harvard University,she invented a super-resolution imaging method (STORM) which employs switchable fluorescent molecules to smash the boundaries imposed by the diffraction limit of traditional microscopes. The result: ultra-high resolution images of molecules and cellular structures10,000x smaller than the width of a human hair. With STORM,her lab hasdiscovered previously unknown cellular structures,such as aperiodic membrane skeleton in neurons in the brain.

Zhijian "James" Chen – University of Texas Southwestern Medical Center and Howard Hughes Medical Institute

Citation:For elucidating how DNA triggers immune and autoimmune responses fromthe interior of acell through the discovery of the DNA-sensing enzyme cGAS.

Description: T-cells and other white blood cells are the frontline fighters of the immune system. BiochemistZhijian (James) Chen has illuminated the workings of an underlying,innate immune system– operating out of every cell in our body that triggers the deployment (or over-deployment) of the fight-back response to virus,stress,radiation and other insults. Chen's lab has shown how DNA brought in by an invader,or seeping out ofa cell'snucleus,is sensed by a protein,that,ultimately,activates the T-cells and white blood cells.He is now working to harness this powerful healing force to stop diseases like cancer; and to rein in the mechanism when it goes awry in auto-immune disorders such as arthritis and lupus.Chengrew up in a remote mountain village in China's Fujian Province. Early in his childhood,he demonstratedan innate curiosity about natureand was encouraged by his parents to pursue a career in science. He emigrated to the US and earned his PhD at SUNY Buffalo. He believes science has no borders and that disease is our common enemy.

"The winners of the Breakthrough Prize in Life Science show us all how it's done," said Cori Bargmann,chair of the selection committee. "Through creativity,innovation,persistence,and skill,each of them brought about an advance that was previously unimaginable."

BREAKTHROUGH PRIZE IN FUNDAMENTAL PHYSICS

Charles Kane and Eugene Mele – University of Pennsylvania

Citation:For new ideas about topology and symmetry in physics,leading to the prediction of a new class of materials that conduct electricity only on their surface.

Description: Since the days of Ben Franklin,we've come to distinguish between electrical forms of matter that are either conducting or insulating. But that concept has been turned inside-out by Charles Kane and Gene Mele who have predicted a new class of materials – "topological insulators" – that are inviolable conductors of electricity on the boundary but insulators in the interior. Their discovery has important implications for the"space-race" inquantum computingand couldlead to new generations of electronic devicesthat promise enormousenergy efficiencies in computation.Topological insulators also offer a window into deep questions about the fundamental nature of matter and energy,since they exhibit particle-like excitations similar to the fundamental particles of physics(electrons and photons) but can be controlled in the laboratory in ways that electrons and photons cannot.These connections offer a newconceptual framework forcontrolling the flow of charge,light and even of mechanical waves in various states of matter. Unanticipated applications,too,seem inevitable: when the transistor was invented in 1947,no one could realistically predict that it would lead to information technologies that would allow terabytes of data to be crammed onto a tiny silicon chip.

"Kane and Mele introduced new ideas of topology in quantum physics in a quite remarkable way," said Edward Witten,chair of the selection committee. "It is beautiful how this story has unfolded."

BREAKTHROUGH PRIZE IN MATHEMATICS

Vincent Lafforgue – CNRS (National Center for Scientific Research,France) and Institut Fourier,Université Grenoble Alpes

Citation: For ground breaking contributions to several areas of mathematics,in particular to the Langlands program in the function field case.

Description: The French lay claim to some of the greatest mathematical minds ever– from Descartes,Fermat and Pascal to Poincaré. More recently Weil,Serre and Grothendieck have given new foundations to algebraic geometry– from which arithmetic geometry was coined.Vincent Lafforgueis a leader of this latter school– now at the heart of new discoveries into cryptography andinformation securitytechnologies.He makes his professional home in Grenoble at the CNRS,the largest fundamental science agency in Europe,where he has a tenured position and free rein to ponder the imponderable.Deeply concerned about the ecological crisis,Lafforgueis now focused onoperator algebrasin quantum mechanics and devising new materials for clean energy technologies.He likes to spend his timehiking in foothills of the Alps.

"Vincent Lafforgue,in the so called 'function field case,' found a beautifully simple direct argument," said Richard Taylor,the chair of the selection committee. "After seeing it you ask yourself how the rest of us could have missed it for so long. You finally see why Langlands correspondence has to exist – it no longer seems an unmotivated miraculous consequence of complicated computations."

SPECIAL BREAKTHROUGH PRIZE IN FUNDAMENTAL PHYSICS

Jocelyn Bell Burnell – University of Dundee and University of Oxford

Citation:For fundamental contributions to the discovery of pulsars,and a lifetime of inspiring leadership in the scientific community.

NEW HORIZONS INPHYSICS PRIZE

Brian Metzger – Columbia University

Citation: For pioneering predictions of the electromagnetic signal from a neutron star merger,and for leadership in the emerging field of multi-messenger astronomy.

Rana Adhikari, Lisa Barsotti and Matthew Evans – California Institute of Technology,Massachusetts Institute of Technology and Massachusetts Institute of Technology,respectively

Citation: For research on present and future ground-based detectors of gravitational waves.

Daniel Harlow, Daniel L. Jafferis and Aron Wall – Massachusetts Institute of Technology,Harvard University and Stanford University,respectively

Citation: For fundamental insights about quantum information,quantum field theory,and gravity.

NEW HORIZONS IN MATHEMATICS PRIZE

Chenyang Xu– Massachusetts Institute of Technology and Beijing International Center for Mathematical Research

Citation:For major advances in the minimal model program and applications to the moduli of algebraic varieties.

Karim Adiprasito and June Huh – Hebrew University of Jerusalem and Institute for Advanced Study,respectively

Citation: For the development,with Eric Katz,of combinatorial Hodge theory leading to the resolution of the log-concavity conjecture of Rota.

Kaisa Matomäki and Maksym Radziwill – University of Turku and California Institute of Technology,respectively

Citation: For fundamental breakthroughs in the understanding of local correlations of values of multiplicative functions.

About the Breakthrough Prizes

For the seventh year,the Breakthrough Prizes will recognize the world's top scientists. Each prize is $3 million and presented in the fields of Life Sciences (up to four per year),Fundamental Physics (one per year) and Mathematics (one per year). In addition,up to three New Horizons in Physics and up to three New Horizons in Mathematics Prizes are given out to junior researchers each year. Laureates attend a live televised award ceremony designed to celebrate their achievements and inspire the next generation of scientists. As part of the ceremony schedule,they also engage in a program of lectures and discussions.

The Breakthrough Prizes are sponsored by Sergey Brin,Yuri and Julia Milner,and Anne Wojcicki. Selection Committees composed of previous Breakthrough Prize laureates in each field choose the winners.

Information on the Breakthrough Prizes is available at breakthroughprize.org.