Pharmaceutical Collaborations and Rare Diseases Drive the Drugs to Watch as New Blockbusters Are Forecast to Hit the Market in 2019

New report from Clarivate Analytics identifies seven new drugs predicted to achieve annual sales of >$1 billion by 2023

Game-changing therapies addressing immune-related and genetic disorders target under-served patient populations

PHILADELPHIA,March 20,2019 --Clarivate Analytics,a global leader in providing trusted insights and analytics to accelerate the pace of innovation,announced today the launch of its annual "Cortellis Drugs to Watch" report. The analysis identified seven new drugs forecasted to achieve annual sales of $1 billion or more (i.e.,blockbuster status) by 2023 using data and analytics from Cortellis,the company's suite of lifescience intelligence solutions. Additionally,the report highlights the impact of strategies and incentives put in place by global regulatory bodies to encourage the focus of drug development on niche markets and unmet medical needs.

The drugs forecasted to launch in 2019 are described in the Appendix below and dominated by immune-related and genetic disorders including: spinal muscular atrophy (SMA),rheumatoid arthritis (RA),paroxysmal nocturnal hemoglobinuria (PNH),and peanut allergy. This indicates a shift toward blockbuster-potential drugs targeting niche patient populations,buoyed by strong collaborations between big and specialty pharma companies to develop these therapies. Analysis also suggests the drugs highlighted in the report face a variety of market scenarios ranging from a first in class therapy with nocompetitors (AR-101 for peanut allergy),to having a single strong opponent (Zolgensma for SMA),to launching into a crowded market (Upadacitinibfor RA),with eachstrategy having its own strengths and weaknesses.For the full list of drugs and their sales projections,please see the link provided below.

"This year's Drug to Watch report demonstrates the impact of regulators' incentives,including accelerated reviews and tax breaks,on drug development that targets rare diseases," explained Mukhtar Ahmed,President of Life Sciences at Clarivate Analytics. "It's extremely encouraging to see how these incentives,along with discovery breakthroughs and new R&D approaches,are positively impacting patients in under-served populations. What's more,these novel treatments demonstrate the power of collaboration across the industry,which ultimately accelerates innovation."

Projections in the Cortellis Drugs to Watch 2019 report were determined using data and analytics in Cortellis,which curates the broadest and deepest sources of intelligence,including 70,000+ pipeline products,325,000+ clinical trials,91,000+ deals,and 165,000 company profiles. For the first time,Cortellis Drugs to Watch forecasts include insights from Cortellis Analytics – Drug Timeline & Success Rates (DTSR),a predictive analytics tool that improves the accuracy of pipeline forecasts vs. traditional methods by 25%.

The full report is available at: https://clarivate.com/drugstowatch2019

Join the conversation on Twitter: @Cortellis | #blockbusterdrugs2019

About the Cortellis Drugs to Watch 2019 Report

Data and analysisfeaturedin this reportwerederived usingCortellis,the suite of life science intelligence solutions fromClarivate Analytics. This includesCortellis Competitive Intelligence,Cortellis Deals Intelligence,Cortellis Regulatory Intelligence,Cortellis Clinical Trials IntelligenceandCortellis Analytics – Drug Timeline & Success Rates,apatent-pending tool that applies machine learning to forecast the timeline and probability of success across all stages of drugdevelopment.

About Cortellis

Cortellis gives life to science by unlocking the hidden insights in data. As an industry-leading solution,Cortellis curates broad and deep sources of intelligence to enable precise,actionable answers to specific questions across the R&D lifecycle — from discovery and clinical development through regulatory submission and commercialization. By supporting data-driven decisions,Cortellis helps pharmaceutical companies,biotech and medical device/diagnostic firms accelerate innovation.

For more information,visit www.clarivate.com/products/cortellis/.

Clarivate Analytics

Clarivate Analytics is a global leader in providing trusted insights and analytics to accelerate the pace of innovation. Building on a heritage going back more than a century and a half,we have built some of the most trusted brands across the innovation lifecycle,including the Web of Science,Cortellis,Derwent,CompuMark,MarkMonitor and Techstreet. Today,Clarivate Analytics is a new and independent company on a bold entrepreneurial mission,to help our clients radically reduce the time from new ideas to life-changing innovations.

For more information,please visitwww.clarivate.com.

Forward-Looking Statements

This press release and oral statements made with respect to information contained in this release may contain forward-looking statements regarding Clarivate Analytics. Forward-looking statements provide Clarivate Analytics' current expectations or forecasts of future events and may include statements regarding anticipated synergies and other future expectations. These statements involve risks and uncertainties including factors outside of Clarivate Analytics' control that may cause actual results to differ materially. Clarivate Analytics undertakes no obligation to update or revise the statements made herein,whether as a result of new information,future events or otherwise.

Media Contact

Jessica Stanek

e: media.enquiries@clarivate.com

Appendix

Drug

Disease

2019

2023

Company (HQ)

1

Upadacitinib *§†|

(ABT-494)

Rheumatoid arthritis

53M

2.20B

AbbVie(US)

2

Zolgensma∆†|‡§

(onasemnogene

abeparvovec; AVXS-101)

Spinal muscular atrophy

449M

2.09B

AveXis(US)

(aNovartissubsidiary)

3

Roxadustat *§

(FG-4592;AZD-9941;

ASP-1517)

Anemia in chronic kidney

disease patients on

dialysis

30M

1.97B

AstraZeneca(UK)

FibroGen(US)

Astellas(JPN)

4

UltomirisƤ|

(ravulizumab; ALXN-1210)

Paroxysmal nocturnal

hemoglobinuria

170M

1.93B

Alexion(US)

5

Skyrizi *|

(risankizumab; BI-655066;

ABBV-066)

Psoriasis

132M

1.74B

Boehringer Ingelheim

(DE)

AbbVie(US)

6

AR-101*†|‡ ‡‡

Peanut allergy

35M

1.17B

AimmuneTherapeutics

(US)

7

LentiGlobin ∆†|‡

(betibeglogene

darolentivec)

Beta-thalassemiain transfusion-dependentpatients

11M

1.12B

bluebird bio(US)

Table: Analysis of 7 new drugs forecast to enter the market in 2019 and achieve blockbuster sales of over $1 billion by 2023

Data was obtained from the Cortellis Competitive Intelligence database as of March 05,2019. Forecasts are in U.S.$ million(M) and billion (B). *=immune-related disease. ∆=genetic disorder. †=Breakthrough Therapy designation. ‡=Fast Track designation. |=Orphan Drug designation. §=Priority Review. ‡‡=first-in-class.

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