Financial year 2018: Boehringer Ingelheim grows and invests

INGELHEIM,Germany,April 17,2019 --

Well-filled research pipeline in oncology,fibrotic diseases,immunology and metabolic diseases

Operating growth outpaces the market in all businesses

Technical integration of the animal health business acquired in 2017 successfully completed

The research-driven pharmaceutical company Boehringer Ingelheim ended 2018 with net sales of 17.5 billion euros. Adjusted for currency effects,as well as one-off effects due to the asset swap with Sanofi in 2017,net sales grew by 4 per cent. At 3.2 billion euros (+2.8%),R&D expenses increased to 18.1 per cent of annual net sales.

In the process,the company has focused on specific therapeutic areas. "We want to make a significant contribution towards a superior treatment of cancer," says Hubertus von Baumbach,Chairman of the Board of Managing Directors. "In addition,we are conducting research,among others,into fibrotic,metabolic and immunological diseases. Our research pipeline is well-filled."

At almost 1 billion euros (+9%),investments in tangible assets were higher than ever before. Operating income again amounted to 3.5 billion euros (-0.4%),while Group profit after tax increased to 2.1 billion euros. "In 2018,the return on net sales increased from 19.3 to 19.8 per cent,while our equity ratio rose from nearly 38 per cent to 40 per cent. Thus we are also a very healthy company from a financial point of view," remarks Michael Schmelmer,Member of the Board of Managing Directors responsible for Finance.

The average number of employees in all regions increased slightly to a total of 50,370 (+2%).

Human pharmaceuticals-- strong portfolio

At 12.6 billion euros,human pharmaceuticals contributed to 72 per cent of total net sales in 2018. Foreseeable declines in net sales,due to expiring patents for innovative medicines,were more than compensated for,this business thereby achieving currency-adjusted growth of 5.1 per cent. Revenues from the global licensing business were lower than in the previous year and have reduced the overall rate of growth in this business area to 3.3 per cent.

As in previous years,the respiratory medicine SPIRIVA® achieved the highest net sales contributions with 2.4 billion euros (-11.4% currency-adjusted),followed by the type-2 diabetes medicine family JARDIANCE®,including SYNJARDY® and GLYXAMBI®,with 1.8 billion euros (+52.5% currency-adjusted),the anticoagulant PRADAXA® with 1.5 billion euros (+7.0% currency-adjusted),the type-2 diabetes medicine TRAJENTA® with 1.4 billion euros (+9.0% currency-adjusted),as well as OFEV® for the treatment of idiopathic pulmonary fibrosis (IPF),with 1.1 billion euros (+28.7% currency-adjusted).

At 2.8 billion euros,research and development investments in human pharmaceuticals corresponded to a 22.1% share of human pharmaceuticals' net sales. For the total of 90 projects in all phases of the research process,the goal is for 75 per cent of them to be either the first molecules in their active ingredient class or the first in a new therapeutic area. In oncology,the focal points are cancers of the lung,stomach and intestine,while in fibrotic diseases the focus is on systemic scleroderma with interstitial lung disease. In metabolic diseases,non-alcoholic steatohepatitis is the main focus of research. In immunology,research is giving attention to chronic inflammatory diseases of the skin and intestine. Other projects address diseases of the central nervous system,such as Alzheimer's and schizophrenia,obesity and retinopathy.

Animal health-- Technical integration completed

In animal health,our focus is on innovative vaccines,antiparasitic medicines and further therapy solutions for livestock and pets. In 2018,the three antiparasitic medicines NEXGARD®,FRONTLINE® and HEARTGARD®,plus the vaccine INGELVAC CIRCOFLEX®,were the four best-selling products. Net sales of 4 billion euros represented 23 per cent of total net sales.

In the second year of the Merial transaction,this business has thereby achieved significant net sales growth,with a currency-adjusted rate of 5.6 per cent,while simultaneously undertaking integration efforts. "We have focused on providing our customers with continuous supply from day one. As a result,we have achieved good growth and the technical integration is successfully completed," says Hubertus von Baumbach. The innovation potential in animal health,where it interrelates with human pharmaceutical research,deserves particular attention.

Biopharmaceutical contract manufacturing maintains lead position

The biopharmaceuticals business maintained its lead position in the contract manufacturing segment in the financial year 2018 and provided 4 per cent of overall net sales. The order situation has continued to develop positively and provided for a high level of capacity utilization in biopharmaceutical production.

Outlook for 2019

For the current financial year,Boehringer Ingelheim is expecting slight growth in net sales and further intensive investment activities on a comparable basis. "In Europe alone we are planning investments of more than 3 billion euros within the next five years," says von Baumbach. "The key precondition for this are competitive overall conditions at our European sites."

Boehringer Ingelheim

Improving the health of humans and animals is the goal of the research-driven pharmaceutical company Boehringer Ingelheim. The focus in doing so is on diseases for which no satisfactory treatment option exists to date. The company therefore concentrates on developing innovative therapies that can extend patients' lives. In animal health,Boehringer Ingelheim stands for advanced prevention.

Family-owned since it was established in 1885,Boehringer Ingelheim is one of the pharmaceutical industry's top 20 companies. Some 50,000 employees create value through innovation daily for the three business areas human pharmaceuticals,animal health and biopharmaceuticals. In 2018,Boehringer Ingelheim achieved net sales of around 17.5billioneuros. R&D expenditure of almost

3.2 billion euros corresponded to 18.1percent of net sales.

As a family-owned company,Boehringer Ingelheim plans in generations and focuses on long-term success. The company therefore aims at organic growth from its own resources with simultaneous openness to partnerships and strategic alliances in research. In everything it does,Boehringer Ingelheim naturally adopts responsibility towards humankind and the environment.

More information about Boehringer Ingelheim can be found on www.boehringer-ingelheim.com or in our annual report: http://annualreport.boehringer-ingelheim.com.

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