Covestro debuts future drug delivery concept in Asia at CMEF

SHANGHAI,May 14,2019 -- Covestro is today attending the China International Medical Equipment Fair (CMEF) spring show - the leading event in China's medical equipment industry. At the event,Covestro will debut its connected drug delivery concept in Asia and showcase solutions for smart wearable devices,surgical applications,renal dialysis and medical device miniaturization.

The connected drug delivery concept from Covestro

"Medical devices have become increasingly miniaturized and intelligent in recent years. Smart wearable devices now include multiple functionalities,e.g. vital sign monitoring,continuous drug delivery,activity tracking and internet connectivity,bringing new possibilities to the development of medical devices," said Dr. Douglas Hamilton,global healthcare segment marketing leader of Business Unit Polycarbonates at Covestro. "Medical-grade plastics are also seeing higher requirements for quality,device productivity and design freedom. Medical-grade plastics from Covestro will enable our customers to tackle these challenges."

With the pace of life actively accelerating,an increasing number of end users expect to improve their own health management and to enjoy more flexibility in terms of medication schedule and locations of treatment,receiving treatment outside clinics and hospitals. Connected,continuous monitoring will enable patients to perform self-monitoring and self-administration of treatment and provide them with autonomy,improved treatment comfort and compliance.

The broad connected wellness market also presents new challenges for material solution providers: the materials for such devices must meet traditional medical device requirements and also ensure safe operation by non-healthcare professionals like patients or their family members.

For the connected drug delivery concept,Covestro used Makrolon® polycarbonate to produce the outer casings. Makrolon® medical-grade polycarbonates have glass-like transparency,offer excellent impact resistance,dimensional stability,design flexibility,durability,and can aid in improving dose accuracy. They meet the strict requirements of a wide range of medical products and are one of the optimal material choices for drug delivery innovation.

Covestro material solutions have also been widely used in portable healthcare devices. Covestro supplied Bayblend® PC/ABS material for the hygrothermograph and digital thermometer made by MMC,a connected healthcare equipment start-up,and also provided ample and timely technical support in their development and production.

Bayblend® is eco-friendly,possesses a halogen-free flame retardant formula and helps their products pass the medical device certification requirements of the China National Medical Products Administration and rigorous medical-grade biocompatibility tests. Moreover,this material features excellent color consistency,smooth surfaces and easy molding of the rounded edgeless design,thus ensuring the high impact resistance of the application at lower production costs.

Needle-free syringes manufactured by Beijing-based QS Medical Technology Co.,Ltd. use Makrolon® Rx1805,a medical-grade polycarbonate supplied by Covestro. The polycarbonate is durable,lipid-resistant,biocompatible and suitable for flexible design. At the same time,Makrolon® polycarbonate can meet the multiple requirements of the ampoules for the needle free injector and the drug delivery component in terms of strength,molding precision,drug inertness and gamma sterilizability.

Also being showcased at the Covestro booth are:

Integrated syringe closure using Apec® 1745 high-heat polycarbonate from Covestro: Prefilled syringes have achieved strong market growth and are widely used in the treatment of chronic diseases such as rheumatism. Apec® 1745 is transparent,heat-resistant and can be sterilized by conventional methods,such as by gamma ray or ethylene oxide. Additionally,this material is dimensionally stable,maintains excellent dimensional accuracy even at high temperatures,and provides superior impact resistance.

Makrolon® Rx3440 from Covestro offers superior durability and chemical resistance to aggressive solvents and enables healthcare professionals to safely deliver oncology drugs to patients.

Makrolon® Rx2235 from Covestro features superior high flow properties and is used for thin wall applications. Meanwhile,it meets the requirements of various medical sterilization options and provides design freedom. This material can be easily used in multi-cavity mold production to reduce part production costs and increase production efficiency.

Also on display will be Maezio(TM),a new continuous fiber-reinforced thermoplastic composite from Covestro and a new option for metal replacement. It has a high specific stiffness and strength compared to magnesium and aluminum while being extremely lightweight. It is also scalable and sustainable.

As an innovative partner,Covestro not only supplies advanced materials to customers,but also provides them with custom solutions for the whole industry chain by means of open innovation. Relying on our experience and expertise,Covestro provides trend insights and regulatory guidance to customers,enabling them to bring their ideas to reality.

The CMEF spring show is being held at the National Exhibition and Convention Center in Shanghai from May 14-17,2019. The booth of Covestro is located in Hall 6.1 (No.: 6.1 O23).

About Covestro:

With 2018 sales of EUR 14.6 billion,Covestro is among the world's largest polymer companies. Business activities are focused on the manufacture of high-tech polymer materials and the development of innovative solutions for products used in many areas of daily life. The main segments served are the automotive,construction,wood processing and furniture,and electrical and electronics industries. Other sectors include sports and leisure,cosmetics,health and the chemical industry itself. Covestro has 30 production sites worldwide and employs approximately 16,800 people (calculated as full-time equivalents) at the end of 2018.

This press release is available at www.covestro.cn. Please acknowledge the source of any pictures used.

Find more information at www.covestro.cn.

Forward-looking statements

This news release may contain forward-looking statements based on current assumptions and forecasts made by Covestro AG. Various known and unknown risks,uncertainties and other factors could lead to material differences between the actual future results,financial situation,development or performance of the company and the estimates given here. These factors include those discussed in Covestro's public reports which are available at www.covestro.com. The company assumes no liability whatsoever to update these forward-looking statements or to conform them to future events or developments.

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